Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbits

SERARSLAN Y., Bal R., ALTUĞ M. E., Kontaş T., Melek I. M.

Pakistan Journal of Pharmaceutical Sciences, cilt.22, sa.3, ss.313-316, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: Pakistan Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.313-316
  • Anahtar Kelimeler: Brain, Caffeic acid phenethyl ester, CAPE, Experimental stroke, MCA, Middle cerebral artery occlusion, S100B
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10μg/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.