Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbits
Pakistan Journal of Pharmaceutical Sciences, vol.22, no.3, pp.313-316, 2009 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 22 Issue: 3
- Publication Date: 2009
- Journal Name: Pakistan Journal of Pharmaceutical Sciences
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.313-316
- Keywords: Brain, Caffeic acid phenethyl ester, CAPE, Experimental stroke, MCA, Middle cerebral artery occlusion, S100B
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10μg/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.