Research Information System
Journal of Clinical and Analytical Medicine, vol.6, no.3, pp.269-273, 2015 (Scopus, TRDizin)
Aim: Thalassemia is accepted to be the most common genetic disease in the world. This study was performed to establish whether there was a glomeru-lar renal damage, which was usually a less mentioned subject in patients with Beta Thalassemia Major, and to compare urea, creatinine and creatinine clearance with early indicators of kidney damage as Cystatin-C and β-2 mi-croglobulin as on determining the glomerular damage. Material and Method: This study was prospectively performed in patients, who were regularly fol-lowed in the children hematology outpatient clinic with a diagnosis of Beta Thalassemia Major. Results: There was no statistically significant difference between urea and levels of creatinine clearance and Cystatin-C. There was a statistically negative relationship between creatinine and creatinine clear-ance at an advanced level as 53.7% (p: 0.002, p<0.01). There was not any significant relationship between Cystatin-C and levels of creatinine and B-2 microglobulin. There was a significant high positive relationship between Cystatin-C and B-2 microglobulin at level of 86.1% (p: 0.001; p<0.01). Dis-cussion: The results of our study were also similar to the literature. However, new studies are required to carry out in wider populations in order to reach definite conclusions about correlation of renal parameters with each other.