Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats

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PINAR N., KARATAŞ Y., Gonlusen G., DAĞLIOĞLU Y. K.

Cukurova Medical Journal, vol.45, no.1, pp.251-256, 2020 (ESCI, TRDizin) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.17826/cumj.648050
  • Journal Name: Cukurova Medical Journal
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.251-256
  • Open Archive Collection: AVESIS Open Access Collection
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Purpose: We investigated the effects of Quercetin andCoenzyme Q10 antioxidant, on gentamicin-induced renalfailure in rats.Materials and Methods: The rats were given gentamicin(100 mg/kg/day, i.m., once a day), gentamicin (100mg/kg/day, i.m.once a day) + Quercetin (15 mg/kg i.p.once a day) and gentamicin (100 mg/kg/day, i.m.) +Coenzyme Q10 (8 mg/kg i.m. once a day).Results: In control the BUN value was 26.8 ± 0.8(mg/100 mL); whereas, it was 117.3 ± 15.4 in gentamicingroup. Renal histopathologic examination confirmed acutetubular necrosis in this group. In rats treated withgentamicin + Quercetin and gentamicin + Coenzyme Q10,a partial improvement in biochemical and histologicparameters was observed. BUN values were 117.3 ± 15.4,44.0 ± 8.3, 47.8 ± 13.8 in gentamicin, gentamicin plusQuercetin and gentamicin plus Coenzyme Q10 treatedgroups, respectively. Creatinine values were 4.3 ± 0.6, 0.8± 0.1, 1.5 ± 0.4 in gentamicin, gentamicin plus Quercetinand gentamicin plus Coenzyme Q10 treated groups,respectively.Conclusion: These results suggest that the administrationof Quercetin and Coenzyme Q10 may have a protectiveeffect on gentamicin-induced nephrotoxicity in rats.