Akademik Veri Yönetim Sistemi
Bulletin of the Veterinary Institute in Pulawy, cilt.51, sa.4, ss.635-640, 2007 (SCI-Expanded)
Thirty male Wistar albino rats were equally divided into two groups. All the animals were sedated with 5 mg kg-1 of xylazine hydrochloride, and then 2.5% isoflurane or 8% desflurane with 100% oxygen by mask induction were given and anaesthesia maintenance was continued for 60 min with 5.7% desflurane or 1.4% isoflurane. Anaesthesia applications were repeated on the 1st, 3rd, and 7th d in both groups. Heart and respiratory rates, rectal temperature, and electrocardiogram recordings were monitored periodically at the control time and at the 15th, 30 th, and 60th min during anaesthesia. Anaesthesia induction and recovery times were also controlled. Compared to the 1st d, the repeated administration of desflurane and isoflurane caused no statistically significant change in QT and QTc intervals. The P wave duration (ms) decreased on the 7th d in both groups (P<0.05), and the R wave amplitude (mV) significantly decreased on the 3rd d in the desflurane group (P<0.05). Although significant differences in the QRS interval (ms) (P<0.001) and R wave amplitude (mV) on the 1st d (P<0.05) were found, their values changed within normal reference ranges and did not lead to left ventricular enlargement. However, anaesthesia induction (P<0.05) and recovery times (P<0.01-0.001) in the desflurane group were performed faster than the isoflurane group. We concluded that a repeated application of desflurane and isoflurane caused no significant QT and QTc prolongation and myocardial repolarisation abnormalities, whereas they decreased anaesthesia induction and recovery times.