Akademik Veri Yönetim Sistemi
BIOLOGY BULLETIN, cilt.52, sa.6, 2025 (SCI-Expanded, Scopus)
This research was purposed to examine the possible neuroprotective effects of 1,8-cineole against cisplatin-induced brain injury in rats. 24 female Wistar Abino rats were randomly divided into four groups: control, 1,8-cineole (cineole), cisplatin, and cisplatin + 1,8-cineole (cisplatin + cineole). The cisplatin and cisplatin + cineole group were applied cisplatin (12 mg/kg, a single dosage, i.p.) on the 1st day of the research. The cineole and cisplatin + cineole group were administered 1,8-cineole (100 mg/kg, once a day, orally) for 7 days. The rats were sacrificed and their brain were removed on the 8th day of the research. In brain of the rats, the values of malondialdehyde (MDA), vitamin C (Vit C), glutathione (GSH), catalase (CAT) and glucose-6-phosphate dehydrogenase (G6PD) were determined by spectrophotometric methods. B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) genes expressions in the apoptosis pathway in brain were analyzed by real-time polymerase chain reaction (RT-qPCR). Cisplatin elevated lipid peroxidation (MDA) and reduced the activity of antioxidants (Vit C, GSH, G6PD, and CAT) in brain. Also, cisplatin induced decrease in Bcl-2 gene expression. Simultaneous administration of 1,8-cineole reduced cisplatin-induced alterations of oxidative stress and apoptotic marker. This study revealed antioxidative, antiapoptotic, and so neuroprotective effects of 1,8-cineole. Thus, it is thought that new studies will shed light on whether 1,8-cineole can be used as an agent that reduces cisplatin-induced neurotoxic effects.