Benefits of renin angiotensin aldosterone system blockage
Aging and The Kidney, Syephen Z. Fadem,Ahmed Arslan Yousuf Awan,Emaad M. Abdel-Rahman, Editör, Elsevier Science, Oxford/Amsterdam , Maine, ss.487-505, 2026
- Yayın Türü: Kitapta Bölüm / Ders Kitabı
- Basım Tarihi: 2026
- Yayınevi: Elsevier Science, Oxford/Amsterdam
- Basıldığı Şehir: Maine
- Sayfa Sayıları: ss.487-505
- Editörler: Syephen Z. Fadem,Ahmed Arslan Yousuf Awan,Emaad M. Abdel-Rahman, Editör
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
The renin-angiotensin-aldosterone system (RAAS) is a hormonal cascade that regulates
blood pressure (BP) and sodium and water balance (Fig. 26.1).
Chronic activation of the RAAS can lead to pathological remodeling of the heart and blood
vessels (Forrester et al., 2018). The RAAS plays an important role in the pathophysiology of
hypertension, heart failure, and chronic kidney disease (CKD) (Forrester et al., 2018). Inhibition
of this system results in decreased circulating levels and biological activity of angiotensin II,
leading to vasodilation, reduced aldosterone secretion, and diminished sympathetic nervous
system activity. Pharmacological blockade of the RAAS is an effective therapeutic strategy
for hypertension, cardiovascular disease, and CKD. However, the older adult population has
specific physiological changes that render them particularly susceptible to complications
from RAAS blockade.