The prevalence of silent cerebral infarct in patients with sickle cell disease Orak hücre hastalarinda sessiz serebral enfarkt sikliǧi

BALCI A., Okuyucu E., Duman T., Gali E., KARAZİNCİR S., Melek I., ...Daha Fazla

Turk Beyin Damar Hastaliklar Dergisi, cilt.14, sa.3, ss.79-82, 2008 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2008
  • Dergi Adı: Turk Beyin Damar Hastaliklar Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.79-82
  • Anahtar Kelimeler: Brain, Magnetic resonance, Sickle cell disease, Silent infarct
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Objective: To determine the prevalence of silent cerebral infarct and abnormal brain magnetic resonance imaging (MRI) findings in patients with sickle cell disease (SCD). Materials and methods: Fifty-two brain MR images of the asymptomatic patients with SCD have been reviewed retrospectively. The abnormal MRI findings were recorded. Results: Forty-four of the 52 patients with SCD were homozygous (S/S) and remaining 8 heterozygous (S/ßthal) for SCD. Twelve (27.2%) of the 44 patients with S/S and 2 (25%) of the 8 patients with S/ßthal had silent infarcts. Ten (22.7%; 7 diffuse cerebral, 2 focal cerebral and 1 cerebellum) of the 44 S/S patients demonstrated atrophy. None of the 8 patients with S/ßthal had cerebral atrophy. Conclusion: Patients with SCD living in Hatay demonstrated a high rate of silent cerebral infarct and cerebral atrophy. These findings concur with the results of the literature.