Effect of colchicine on polycystic ovary syndrome: an experimental study

Gozukara I. O., PINAR N., ÖZCAN O., ÖZGÜR T., Dokuyucu R., Kurt R. K., ...Daha Fazla

Archives of Gynecology and Obstetrics, cilt.293, sa.3, ss.675-680, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 293 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00404-015-3933-5
  • Dergi Adı: Archives of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.675-680
  • Anahtar Kelimeler: Colchicine, Metformin, PCOS
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Purpose: To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS). Methods: Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E1), estradiol (E2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated. Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment. Conclusion: Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.