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International Journal of Ophthalmology, vol.7, no.2, pp.340-344, 2014 (SCI-Expanded)
AIM To investigate and compare the cy topathological and clinical effects of amniotic membrane transplantation (AMT) and oral mucosal membrane transplantation (OMMT) in socket contraction. METHODS Twelve patients who could not be fitted with ocular prosthesis due to socket contracture were included in this study . Seven patients underwent AMT and 5 patients underwent OMMT. Thirteen patients who had healthy sockets were included as control group. Depth of inferior fornix, degree of inflammation, extent of the socket contracture and socket volume were measured in the preoperative period and at sixth and twelfth weeks postoperatively. Impression cytology of conjunctival fornices and tear transforming growth factor beta-1 (TGFPi ) levels were determined. RESULTS In the AMT group, socket volume and lower fornix depth values were significantly higher (P=o.O3O and P=O.OO4 respectively) and inflammation levels and impression cytology stages (^=0.037 and P=o.O22 respectively) were significantly lower in postoperative period compared to preoperative period. In the OMMT group, no statistical differences were found in terms of clinical parameters, inflammation levels and impression cytology stages of preoperative versus postoperative values. Preoperative tear TGFPi levels were higher in AMT and OMMT groups compared to the control group (25 .5 ng/mL, 26 .3 ng/mL and 21.7 ng/mL respectively). Decreased tear TGFPi levels were observed in both the AMT and OMMT groups postoperatively (median decrease value=2 .1 ng/mLand2.7 ng/mL respectively). CONCLUSION AMT is associated with postoperative improvement in inferior fornix depth, socket volume, inflammation and impression cytology levels and may be a more proper alternative method than OMMT in the management of socket contracture. © International Journal of Ophthalmology Press.