Is periodontal inflamed surface area associated with serum and salivary levels of IL-1β, visfatin, and omentin-1 in overweight/obese patients?
CLINICAL ORAL INVESTIGATIONS, sa.8, ss.5351-5358, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s00784-022-04502-0
- Dergi Adı: CLINICAL ORAL INVESTIGATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Sayfa Sayıları: ss.5351-5358
- Anahtar Kelimeler: Adipokines, Obesity, Overweight, Periodontal diseases
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
Objectives The aim of this study was to evaluate the levels of salivary and serum interleukin (IL)-1 beta, visfatin, and omentin-1 in the relationship between periodontal disease and overweight/obesity as well as to reveal the possible role of periodontal inflamed surface area (PISA) in this association. Materials and methods Ninety-six individuals (69 females, 27 males) were divided into 4 groups as systemically healthy (H) and non-periodontitis (HnP, n=23), systemically healthy and periodontitis (HP, n= 24), overweight/obese (O) and nonperiodontitis (OnP, n=25), and overweight/obese and periodontitis (OP, n =24). Periodontal parameters were measured, and PISA was calculated. IL-1 beta, visfatin, and omentin-1 levels in saliva and serum samples were analysed. Results Periodontal parameters deteriorated, salivary and serum IL-1 beta and visfatin levels were increased, and omentin-1 levels were decreased in OnP and OP groups, compared to HnP and HP groups. Salivary and serum IL-1 beta and visfatin levels were increased and omentin-1 levels were decreased in periodontitis groups, compared to HnP and OnP groups. PISA was negatively correlated with salivary omentin-1 and positively correlated with salivary and serum visfatin in H and O groups, whereas a positive relationship was found between PISA and salivary and serum IL-1 beta in H group. Conclusions PISA may be negatively associated with salivary omentin-1, while positively correlated with salivary and serum visfatin in overweight/obese patients.