The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates

Ghica M. V., Albu M. G., KAYA D. A., Popa L., Öztürk Ș., Rusu L., ...Daha Fazla

Korean Journal of Chemical Engineering, cilt.33, sa.4, ss.1325-1330, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s11814-015-0284-7
  • Dergi Adı: Korean Journal of Chemical Engineering
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1325-1330
  • Anahtar Kelimeler: Collagen Hydrolysate, Lavandula Essential Oils, Niflumic Acid, Release Kinetics
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.