VEGF 936 C/T gene polymorphism in renal transplant recipients: Association of the T allele with good graft outcome

GÜNEŞAÇAR R., Opelz G., Erken E., Pelzl S., Döhler B., Ruhenstroth A., ...Daha Fazla

Human Immunology, cilt.68, sa.7, ss.599-602, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.humimm.2007.03.015
  • Dergi Adı: Human Immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.599-602
  • Anahtar Kelimeler: Gene polymorphism, Graft outcome, Renal transplantation, VEGF
  • Hatay Mustafa Kemal Üniversitesi Adresli: Hayır

Özet

We investigated the possible impact of vascular endothelial growth factor (VEGF) 936 C/T gene polymorphism on kidney graft outcome. DNA samples of 290 first deceased donor kidney graft recipients with well-functioning grafts and no rejection treatment during the first transplant year (WFG), 265 recipients with graft failure within the first transplant year (F), and 187 healthy control subjects were tested using the polymerase chain reaction restriction fragment length polymorphism technique. Although VEGF 936 CT genotype and T allele carrier frequencies in 555 kidney graft recipients did not differ significantly from frequencies observed in healthy control subjects, significantly higher frequencies were found in WFG patients (CT: 19.0%, T: 20.7%) than in F patients (CT: 11.7%, p = 0.019; T: 12.8%, p = 0.017, respectively). The VEGF 936 CT genotype and T allele appear to be associated with good outcome in renal transplantation and, if confirmed, might be helpful for the pretransplant identification of recipients with low risk of graft rejection. © 2007 American Society for Histocompatibility and Immunogenetics.