Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the mediterranean basin

Bertolotti L., Mazzei M., Puggioni G., Carrozza M., dei Giudici S., Muz D., ...Daha Fazla

Journal of General Virology, cilt.92, sa.8, ss.1923-1929, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1099/vir.0.032334-0
  • Dergi Adı: Journal of General Virology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1923-1929
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Small ruminant lentiviruses (SRLVs) represent a group of viruses infecting sheep and goats worldwide. Despite the high heterogeneity of genotype A strains, which cluster into as many as ten subtypes, genotype B was believed to be less complex and has, so far, been subdivided into only two subtypes. Here, we describe two novel full-length proviral sequences isolated from Sarda sheep in two Italian regions. Genome sequence as well as the main linear epitopes clearly placed this cluster into genotype B. However, owing to long-standing segregation of this sheep breed, the genetic distances that are clearly >15% with respect to B1 and B2 subtypes suggest the designation of a novel subtype, B3. Moreover the close relationship with a gag sequence obtained from a Turkish sheep adds new evidence to historical data that suggest an anthropochorous dissemination of hosts (small ruminants) and their pathogens (SRLV) during the colonization of the Mediterranean from the Middle East. © 2011 SGM.