Sulfasalazine-induced hypersensitivity syndrome in a 15-year-old boy associated with human herpesvirus-6 reactivation

Balci D. D., Peker E., DURAN N., Dogramaci C. A.

Cutaneous and Ocular Toxicology, vol.28, no.1, pp.45-47, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1080/15569520802696250
  • Journal Name: Cutaneous and Ocular Toxicology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-47
  • Keywords: Drug-induced hypersensitivity syndrome, Human herpesvirus-6 reactivation, Sulfasalazine
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DIHS and has prognostic importance. We report a 15-year-old boy with juvenile rheumatoid arthritis who developed DIHS due to sulfasalazine, associated with reactivation of HHV-6. © 2009 Informa UK Ltd.