Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep
Journal of Veterinary Pharmacology and Therapeutics, vol.47, no.3, pp.202-207, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 47 Issue: 3
- Publication Date: 2024
- Doi Number: 10.1111/jvp.13422
- Journal Name: Journal of Veterinary Pharmacology and Therapeutics
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database
- Page Numbers: pp.202-207
- Keywords: increasing dose, meloxicam, pharmacokinetics, sheep
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15-day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters were evaluated by non-compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non-linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of ≥1 mg/kg in sheep.