N-Terminal Pro-Brain Natriuretic Peptide Level is Associated with Severity and Complexity of Coronary Atherosclerosis in Patients with Acute Coronary Syndrome

Kurtul A., Yarlioglues M., Murat S. N., Duran M., Acikgoz S. K., Sensoy B., ...More

Clinical and Applied Thrombosis/Hemostasis, vol.22, no.1, pp.69-76, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1177/1076029614541954
  • Journal Name: Clinical and Applied Thrombosis/Hemostasis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.69-76
  • Keywords: acute coronary syndrome, N-terminal pro-brain natriuretic peptide, syntax score
  • Hatay Mustafa Kemal University Affiliated: No

Abstract

N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with short- and long-term mortality in acute coronary syndrome (ACS). We investigated whether baseline NT-proBNP levels are associated with burden of coronary atherosclerosis assessed by SYNTAX score (SXScore). We enrolled 509 patients with ACS who underwent coronary angiography. The patients were divided into tertiles according to the SXScore: low SXScore (≤22), intermediate SXScore (23-32), and high SXScore (≥33). The NT-proBNP levels demonstrated an increase from low SXScore tertile to high SXScore tertile. The NT-proBNP levels according to the SXScore tertiles are as follows: low and intermediate (median 635 vs 1635, P =.014), low and high (median 635 vs 4568, P <.001), and intermediate and high (median 1635 vs 4568, P <.001). In multivariate analysis, NT-proBNP remained an independent predictor of high SXScore (odds ratio: 2.688, 95% confidence interval: 1.315-5.494, P =.007) together with age (P =.002), neutrophil-lymphocyte ratio (P =.017), and presence of non-ST-segment elevation ACS (P =.002). The NT-proBNP was independently associated with burden of coronary atherosclerosis in patients with ACS.