Isotretinoin treatment in patients with acne vulgaris: Does it impact muscle strength, fatigue, and endurance?

Yildizgoren M. T., Rifaioglu E. N., Demirkapi M., Ekiz T., Micoogullari A., ŞEN T., ...More

Cutis, vol.96, no.1, pp.33-36, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 1
  • Publication Date: 2015
  • Journal Name: Cutis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-36
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

The objective of this study was to evaluate the effects of isotretinoin on muscle strength, fatigue, and endurance in patients with acne vulgaris. The study included 27 patients with acne vulgaris who underwent treatment with isotretinoin as well as 26 control patients for comparison. Participants in the treatment group received oral isotretinoin 0.5 mg/kg once daily for 1 month followed by an increased dose of 1 mg/kg once daily for 2 months. Isokinetic measurements were obtained from the hamstrings and quadriceps on the nondominant side of the body at baseline and 3-month follow-up using an isokinetic dynamometer. Results indicated that systemic isotretinoin did not significantly alter muscle strength, fatigue, and endurance.