Pharmacokinetics of tolfenamic acid in ducks (<i>Anas platyrhynchos domestica</i>) after different administration routes
BRITISH POULTRY SCIENCE, cilt.66, sa.2, ss.187-192, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 66 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/00071668.2024.2410365
- Dergi Adı: BRITISH POULTRY SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.187-192
- Anahtar Kelimeler: Bioavailability, duck, HPLC, pharmacokinetics, tolfenamic acid
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
1. The objective of this research was to compare the pharmacokinetics and bioavailability of tolfenamic acid, analgesic, antipyretic and anti-inflammatory compound, after administration through different routes to Pekin ducks. The investigation was carried out over four time periods using a randomised cross-pharmacokinetic design.2. Tolfenamic acid was administered to ducks intravenously, intramuscularly, subcutaneously and orally at a dose of 2 mg/kg. Tolfenamic acid analysis was performed using HPLC-UV and pharmacokinetic data were conducted by non-compartmental analysis.3. The total clearance, volume of distribution at steady state and terminal elimination half-life after intravenous administration were 0.14 l/h/kg, 0.29 l/kg and 1.80 h, respectively. The peak plasma concentration and bioavailability for intramuscular, subcutaneous and oral administration were 4.59, 3.55 and 2.23 mu g/ml and 93.62, 74.30 and 43.43%, respectively.4. Tolfenamic acid was absorbed rapidly, eliminated quickly and exhibited a small distribution volume in Pekin ducks. Pharmacokinetic parameters, including maximum concentration, area under the plasma concentration - time curve and bioavailability, were found to be different in ducks from other bird species.