Akademik Veri Yönetim Sistemi
REVISTA INTERNACIONAL DE ANDROLOGIA, cilt.19, sa.1, ss.41-48, 2021 (SCI-Expanded, Scopus)
Introduction: In our study, we sought answers to many questions about male infertility from a different perspective. The first step in male infertility is anamnesis, physical examination and sperm count. The European Academy of Andrology recommends examination of genetic causes in individuals with fewer than 5 million/ml semen counts. The American Urological Association and American Society for Reproductive Medicine have guidelines recommending performing karyotype and AZF subgroup deletion testing in azoospermia and fewer than 5 million sperm total count. Klinefelter syndrome and Y chromosome microdeletions are still very important in male infertility. Based on patients with Klinefelter syndrome or Y microdeletion, we sought answers to many questions in male infertility. Materials and methods: In the presented study 327 male patients with having fewer than 15 million sperm/ml detected in at least two consecutive sperm analysis were examined. Patients were divided into sub-groups according to the presence of semen count, chromosomal anomaly and Y microdeletion. In addition, FSH, LH and testosterone levels were analyzed. Results: Numerical chromosomal anomalies were observed in 34 (10.4%) of 327 patients, and all of these anomalies were found as 47, XXY. Individuals with no AZF microdeletion constituted 95.1% (n = 311) of the study group. The overall frequency of AZF microdeletions was 4.9% (16/327). No AZF microdeletions were detected for the patients who have sperm counts above 2 million/ml. FSH, LH and testosterone levels were found significantly different between the groups. Discussion: The results of our study provide another layer of evidence to demonstrate the controversial threshold value of the EAA. In light of our data and current literature, we recommendto set the threshold value at 2 million/ml for semen analysis. Further studies conducted in different ethnic groups and larger patient groups would contribute to clarify what exact valueshould be used to apply genetic tests. (C) 2019 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espanola, S.L.U. All rights reserved.