Akademik Veri Yönetim Sistemi
Materials Today Communications, cilt.52, 2026 (SCI-Expanded, Scopus)
Skin lesions affect hundreds of millions of people globally, causing thousands of deaths, generating a billion-dollar wound dressing market, which needs effective management strategies. In this context, the development of new spongious delivery systems is of great interest due to their tissue-like biological nature. Collagen/hydroxyethylcellulose (HEC) spongious matrices, un- and glutaraldehyde (GA) cross-linked, loaded with naproxen (NPX), were developed using a 3-factor, 3-level Box-Behnken factorial plan through the freeze-drying process. Novel matrices were evaluated by spectral, morphological, goniometric, biological, and biopharmaceutical analyses. Spectral analysis indicated the collagen triple helix structure. Morphological and goniometric studies illustrated porous structures and hydrophilic surfaces, with adequate swelling and biodegradation profiles. Drug release followed a biphasic pattern of naproxen, suitable to ameliorate the local inflammation and pain. Optimization process using response surface methodology and the Taguchi approach was used to select the optimal formulations. Treating the experimentally induced burns on Wistar rats with optimal matrices promoted the burns’ healing due to inflammation reduction and cutaneous tissue restoration. Correlating all the results, newly designed spongious delivery systems could be used as promising wound dressings, representing a successful treatment option for burn healing compared with those from the existing market.