Akademik Veri Yönetim Sistemi
Acta Anaesthesiologica Italica, cilt.45, sa.4, ss.75-80, 1994 (Scopus)
Addition of fentanyl, morphine or fentanyl and morphine to bupivacaine administered for epidural anaesthesia was evaluated in eighty healthy patients. The patients were randomized into four equal groups to receive epidural anaesthesia in a double blind design, 20 ml of 0.5% bupivacaine (group 1), 20 ml of 0.5% bupivacaine with 75 μg fentanyl (group 2), 20 ml of 0.5% bupivacaine with 30 μg fentanyl and 1.5 mg morphine (group 3) and 20 ml of 0.5% bupivacaine with 3 mg morphine (group 4). The times for sensory block to develop bilaterally to T12, the time to achieve maximal sensory block, time to request postoperative analgesia and side effects were assessed. The onset time of sensory anaesthesia to T12 was significantly shorter in groups 2 and 3 (4.4 ± 1.2 and 4.1 ± 1 min. vs 6.8 ± 1.8 min. in group 1 and 6.25 ± 1.2 min, in group 4). There mere no significant differences in the, time to achieve maximal sensory block in any group. Duration of analgesia assessed during postoperative period was significantly longer in groups 3 and 4 (1209 ± 860 min. in group 3, 1224 ± 854 min. in group 4 vs 290.1 ± 60 min. in group 1 and 471.1 ± 96 min. in group 2). A decrease in mean arterial pressure of more than 30% of baseline values as observed 10-15% in each group.