Akademik Veri Yönetim Sistemi
Israel Journal of Veterinary Medicine, cilt.75, sa.3, ss.161-167, 2020 (SCI-Expanded)
The aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs.