Potential neoplastic effects of parathion-methyl on rat liver

Coral M. N. U., Ucman S., YILDIZ H., Haydar O., Semih D.

Journal of Environmental Sciences, cilt.21, sa.5, ss.696-699, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/s1001-0742(08)62326-8
  • Dergi Adı: Journal of Environmental Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.696-699
  • Anahtar Kelimeler: Ames test, atypical acinar cell focuses, carcinogenesis, parathion-methyl
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic. © 2009 The Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences.