Dextran Sulfate-STMP Crosslinked Hydrogels Incorporating Copper for Controlled 5-Aminosalicylic Acid Delivery
STARCH-STARKE, cilt.78, sa.10, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 10
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/star.70304
- Dergi Adı: STARCH-STARKE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Compendex, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
In this study, dextran sulfate (DS)/sodium trimetaphosphate (STMP) hydrogel was synthesized through intermolecular side-chain reaction of DS hydroxyl groups with STMP crosslinking agent; at 50 degrees C under basic conditions. DS/STMP-copper nanoparticle composite hydrogel was prepared by the reduction of Cu2+ ions coordinated with hydrogel network. The structure of the obtained hydrogel was characterized using elemental analysis (C, H, and S) and Fourier Transform Infrared (FT-IR) spectroscopy. Swelling behavior of the hydrogel was investigated in three different conditions. Surface morphologies and crystal structures of the DS/STMP hydrogel, DS/STMP/Cu2+ composite hydrogel, and DS/STMP/Cu nanoparticle composite hydrogel were determined by using scanning electron microscopy (SEM) and x-ray diffraction (XRD) analyses. Thermal stabilities of the DS/STMP hydrogel and DS/STMP/Cu2+ composite hydrogel were characterized by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analyses. Drug delivery behavior of DS/STMP/Cu nanoparticle composite hydrogel for 5-aminosalicylic acid (5-ASA) was investigated. Drug delivery studies were carried out using ultraviolet-visible (UV-vis) spectrophotometer. Release of 5-ASA from the DS/STMP/Cu nanoparticle composite hydrogel in representative gastrointestinal pH condition (pH = 7.4) occurred in about 110 min. The synthesized composite hydrogel is thought to have potential applications in drug delivery within the gastrointestinal system, particularly in 5-ASA release.