Akademik Veri Yönetim Sistemi
Ankara Universitesi Veteriner Fakultesi Dergisi, cilt.73, sa.1, ss.83-92, 2026 (SCI-Expanded, Scopus, TRDizin)
A plant-derived monoterpene, eucalyptol (1,8-cineole), has been suggested to have antioxidant, anti-inflammatory, and antimicrobial properties. The wound-healing effects of eucalyptol remain unknown. This study aimed to evaluate the topical use of eucalyptol at two concentrations on a full-thickness excisional skin wound model in terms of wound healing, gene expression, biochemical changes, and histopathological changes. Sixty Wistar rats were randomly divided into 5 groups (n = 12 per group). The control group (C) was untreated. Full-thickness excisional skin wounds were created in the following groups: the vehicle group (V), which was treated with polysorbate 80 solution (negative control). The Dexpanthenol group (D) was treated with dexpanthenol ointment (positive control). Eucalyptol 5% (E5) and Eucalyptol 10% (E10) groups were treated with 5% and 10% eucalyptol, respectively. Wound areas were measured on days 1, 4, 7, 11, 14, 18, and 21 days after wound creation. Wound tissues were collected on days 7 and 21. Histopathological, gene expression (TNFα, IL10, TGFβ1, VEGF), and biochemical (MDA, rGSH, GPx, CAT) analyses were performed on the wound tissues. TNFα gene expression levels were upregulated in Groups V and E5 (P<0.05). IL10 levels were upregulated in the V, E5, and E10 groups (P<0.05). TGFβ1 was upregulated in all groups compared with the control. Significant differences in rGSH, GPx, CAT, and MDA levels were found among all groups (P<0.05). Topical administration of 10% eucalyptol accelerates wound healing. With respect to epidermal thickness, 5% eucalyptol resulted in superior wound healing. Further studies should include different wound models, tissue analyses, and combinations of eucalyptol with other agents.