Effect of 1-deamino 8-d-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis

Akoǧlu E., GÖRÜR S., Atik E., Okuyucu Ş., Sangün Ö.

International Journal of Pediatric Otorhinolaryngology, cilt.70, sa.11, ss.1919-1922, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ijporl.2006.06.019
  • Dergi Adı: International Journal of Pediatric Otorhinolaryngology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1919-1922
  • Anahtar Kelimeler: DDAVP spray, Nasal mucosa, Nocturnal enuresis, Vasopressin
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Objective: To determine any possible adverse effect of 1-deamino 8-d-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis. Methods: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray. Results: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy. Conclusion: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time. © 2006 Elsevier Ireland Ltd. All rights reserved.