Manufacturing nanostructured chitosan-based 2D sheets with prolonged antimicrobial activity

Ficai D., Ardelean I. L., Holban A. M., Diţu L. M., Gudovan D., Sönmez M., ...Daha Fazla

Romanian Journal of Morphology and Embryology, cilt.59, sa.2, ss.517-525, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 2
  • Basım Tarihi: 2018
  • Dergi Adı: Romanian Journal of Morphology and Embryology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.517-525
  • Anahtar Kelimeler: Biomedical applications, Chitosan, Composite materials, Hydrogels, Multifunctional wound dressing
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

The purpose of this study was to synthesize, characterize and test the antimicrobial and antifungal activity of chitosan-based hydrogels containing metal (silver – Ag) and oxide (zinc oxide – ZnO) nanoparticles (NPs) but also natural compounds such as usnic acid (UA). The two-dimensional (2D) sheets were obtained by electrospinning technique, with the aim to produce multifunctional wound dressing with regenerative and even anti-infective roles. The most important advantages of the electrospinning technique are related to the possibility of obtaining fibers with controlled morphology, usually having high specific surface and water and air penetration and the possibility of functionalizing these fibers and nets depending on the desired application. These advantages make it possible to use electrospinning for a wide range of biomedical applications, such as tissue engineering, controlled release, implantology, wound healing, and more. The obtained composite materials were characterized by infrared (IR) spectroscopy and scanning electron microscopy (SEM) and tested against common pathogens: Pseudomonas aeruginosa (Gram-negative staining), Staphylococcus aureus (Gram-positive staining) and Candida albicans (fungus).