Akademik Veri Yönetim Sistemi
5th International Eurasian Conference on Science, Engineering and Technology, Ankara, Türkiye, 26 - 28 Haziran 2024, (Özet Bildiri)
The study aimed to determine the effect of tyrosol on the oxidant-antioxidant status in the heart tissue of rats administered thioacetoamide (TAA). Male Wistar albino rats were divided into four groups: control, thioacetoamide (TAA), tyrosol (Tyr), and thioacetoamide (TAA+Tyr) (n = 28; 7 per group). The experimental model was set for ten weeks. The relevant groups received TAA (200 mg/L, drinking water) and tyrosol (20 mg/kg/day, oral) throughout the study. The oxidative stress parameters malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), and catalase (Cat) levels were measured in the heart samples obtained at the end of the study. In the study, tyrosol showed antioxidant activity by reducing increased MDA (p = 0.003) levels, decreased GSH (0.009), GSH-Px (p = 0.007), and catalase (p = 0.011). As a result, tyrosol shows antioxidant activity by reducing lipid peroxidation and stimulating antioxidant enzymes in the oxidant state caused by TAA in the heart.