Ex vivo tracheal mucociliary clearance in rats: Comparisons of nebulization versus irrigation with lactated ringer and saline solutions

Okuyucu S., Akoglu E., Babayigit C., Akoglu S., Dagli S.

Journal of Otolaryngology - Head and Neck Surgery, cilt.38, sa.4, ss.422-426, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2310/7070.2009.080193
  • Dergi Adı: Journal of Otolaryngology - Head and Neck Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.422-426
  • Anahtar Kelimeler: Irrigation, Lactated ringer solution, Mucociliary clearance, Nebulization, Rat, Saline, Trachea
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Objective: This study was performed to compare the effects of isotonic saline, hypertonic saline (buffered/nonbuffered), and lactated Ringer irrigation and distilled water nebulization on mucociliary clearance in ex vivo rats. Design: Experimental study. Setting: Tertiary otolaryngology care centre. Methods: Thirty rat tracheas were achieved from 15 rats by dividing the trachea longitudinally into two equal parts. Main Outcome Measures: Mucociliary transport velocity was measured by direct observation of particle placed on the lower end of the trachea after irrigation or nebulization. Results: Significant improvement in mucociliary clearance was found with isotonic saline (p = .002), buffered hypertonic saline (p = .018), lactated Ringer (p = .000), and nebulized distilled water (p = .000) when compared with nonbuffered hypertonic saline. Conclusion: Lactated Ringer solution is better than saline solution at enhancing mucociliary clearance, but nebulized distilled water is superior to the tested irrigation solutions in rat tracheal epithelium. © 2009 The Canadian Society of Otolaryngology-Head & Neck Surgery.