Stafilokoklarda Dezenfektan/Antiseptik Direnç Genleri ve Klinik Stafilococcus aureus izolatlarının serotiplendirmesi


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Bayraktar H. S., Köksal F., Duran N., Kandemir T., Baykara B., Güven Gökmen T., ...Daha Fazla

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, cilt.20, sa.2, ss.219-228, 2026 (SCI-Expanded, Scopus)

Özet

Introduction: Staphylococci are commonly isolated from healthcare settings worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important causes of nosocomial infections. Objectives: This study aims to evaluate the resistance of Staphylococci to the most commonly used disinfectants and antiseptics in healthcare settings and the detection of the dominant serotype of Staphylococcus aureus in Hatay province.Methodology: The frequency of disinfectant/antiseptic resistance genes was detected by the polymerase chain reaction (PCR) technique in identified staphylococcal strains, and antibiotic susceptibility of strains was evaluated phenotypically. Staphylococcus aureus strains were classified in terms of clonal and phylogenetic relationships with Pulse Field Electrophoresis and spa sequence typing methods.Results: The identification rate of coagulase-negative staphylococci was 43.2% and the others (56.8%) were Staphylococcus aureus. Among these isolates, 103 methicillin-resistant S. aureus were identified. It was determined that 81 (78.64%) of these isolates harbored qacA/B and/or smr genes. The dominant spa serotype was found to be t223.Conclusions: According to spa serotyping results, it was detected the serotype t223 was the dominant clone in our region, unlike the t030 was dominant in Turkey. Since there are many Syrian immigrants living in the Hatay region due to its geographical location, being the dominant clone of a different serotype has an epidemiologically significant importance