Subclinical left ventricular dysfunction in multiple sclerosis

Akgül F., Mclek I., Duman T., Seyfelì E., Seydaliyeva T., YALÇIN F.

Acta Neurologica Scandinavica, cilt.114, sa.2, ss.114-118, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1600-0404.2006.00662.x
  • Dergi Adı: Acta Neurologica Scandinavica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.114-118
  • Anahtar Kelimeler: Multiple sclerosis, Tissue doppler, Ventricular function
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Objectives - To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods - A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results - LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P < 0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions - These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS. © Blackwell Munksgaard 2006.