Effects of Dexamethasone on Bupivacaine-Induced Peripheral Nerve Injection Injury in the Rat Sciatic Model
Journal of Investigative Surgery, cilt.34, sa.12, ss.1339-1347, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 12
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/08941939.2020.1805053
- Dergi Adı: Journal of Investigative Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EBSCO Legal Collection, EBSCO Legal Source, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1339-1347
- Anahtar Kelimeler: bupivacaine, dexamethasone, Nerve injury
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
Introduction: The aim of this study was to investigate the effect of perineural dexamethasone against intraneural bupivacaine. Material and Methods: Rats were divided into 9 groups with 6 animals in each group; Group 1 (Intraneural saline 600 µL–2ndday), Group 2 (Intraneural saline 600 µL–7th day), Group 3 (Intraneural saline 600 µL + perineural dexamethasone 0.5 mg/kg-2nd day), Group 4 (Intraneural saline 600 µL + perineural dexamethasone 0.5 mg/kg-7th day), Group 5 (Intraneural bupivacaine 10 mg/kg–2nd day), Group 6 (Intranueral bupivacaine 10 mg/kg–7th day), Group 7 (Intraneural bupivacaine 10 mg/kg + perineurald exam ethasone 0.5 mg/kg-2nd day), Group 8 (Intraneural bupivacaine 10 mg/kg + perineural dexamethasone 0.5 mg/kg-7th day), Group 9 (Control group). At the end of the application period, histopathological and immunohistochemical examinations were analyzed. Results and Conclusion: It was observed that caspase 3 levels significantly increased in the 5th and 6th groups compared to the 1st and 2nd groups (p < 0.01). However, in the 7th and 8th groups, these levels were similar with 1st and 2nd groups. While a significant decrease in S 100 levels was detected in group 6 (p < 0.05), a significant increase occurred in Group 8 and reached the same levels as Group 2. According to histopathological evaluation, edema, vacuolization and myelin degeneration were significantly increased in groups 5 and 6 (p < 0.05). However, in the 8th group, the mentioned data showed a significant decrease and reached the same levels as group 2. As a result, perineural dexamethasone was found to have protective effects against intraneural bupivacaine induced sciatic nerve damage.