Mild to Moderate Renal Impairment Is Associated with No-Reflow Phenomenon after Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction

Kurtul A., Murat S. N., Yarlioglues M., Duran M., Celik I. E., Kilic A.

Angiology, vol.66, no.7, pp.644-651, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.1177/0003319714546738
  • Journal Name: Angiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.644-651
  • Keywords: acute myocardial infarction, estimated glomerular filtration rate, no-reflow phenomenon, primary percutaneous coronary intervention
  • Hatay Mustafa Kemal University Affiliated: No

Abstract

We investigated whether admission estimated glomerular filtration rate (eGFR) values are associated with no-reflow phenomenon in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Patients (n = 673; 59 ± 13 years; 77.1% men) were stratified into 3 groups according to eGFR at admission: normal renal function (eGFR ≥ 90 mL/min/1.73 m2), mild renal impairment (eGFR 60-89 mL/min/1.73 m2), and moderate renal impairment (eGFR 30-59 mL/min/1.73 m2). No-reflow phenomenon was defined as thrombolysis in myocardial infarction flow grade <3 after pPCI. The rate of no-reflow gradually increased from the normal renal function group to the moderate impaired renal function group (P <.001). Multivariate analysis showed that eGFR (odds ratio [OR] 0.942, P <.001), Killip ≥2 class (OR 3.968, P =.008), left ventricular ejection fraction (OR 0.959, P =.034), and early patency of infarct vessel (OR 0.186, P <.001) were independent predictors of no-reflow phenomenon. Mild to moderate renal impairment at admission is independently associated with no-reflow phenomenon after pPCI.