AIDS-related and non-AIDS causes of in-hospital death among people living with HIV: a multicenter retrospective study
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2026 (SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/09540121.2026.2729941
- Dergi Adı: AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
- Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, BIOSIS, CINAHL, Educational research abstracts (ERA), EMBASE, Gender Studies Database, MEDLINE, Psycinfo, Public Affairs Index, Violence & Abuse Abstracts, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Social Science Premium Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Psychology & Behavioral Sciences Collection (EBSCO), Sociology Database (ProQuest), Sociology Source Ultimate (EBSCO)
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
Despite advances in antiretroviral therapy (ART), mortality remains an important concern among people living with HIV (PLWH). This study described the causes of in-hospital death and compared AIDS-related and non-AIDS-related deaths among 138 adults PLWH who died during hospitalization at 12 tertiary-care HIV centers in T & uuml;rkiye between 2014 and 2025. Demographic, clinical, and HIV-related data were collected from medical records. Causes of death were classified as AIDS-related or non-AIDS-related using ICD-10-coded diagnoses and CDC/WHO AIDS-defining conditions. Overall, 138 in-hospital deaths were analyzed. AIDS-related deaths accounted for 56.5%. The leading AIDS-related causes were Pneumocystis jirovecii pneumonia, toxoplasmic encephalitis, and tuberculosis, whereas sepsis and respiratory conditions predominated among non-AIDS-related deaths. AIDS-related deaths were characterized by lower CD4 cell counts and more frequent AIDS-defining illness at diagnosis. Smoking (OR = 7.23, 95% CI 1.07-48.75, p = 0.042) and AIDS-defining illness at diagnosis (OR = 6.18, 95% CI 1.18-32.32, p = 0.031) were independently associated with AIDS-related rather than non-AIDS-related in-hospital death. AIDS-related causes remain prominent among in-hospital deaths despite the ART era. Earlier HIV diagnosis, timely ART initiation, and optimized prevention and management of opportunistic infections and comorbidities are essential to improve outcomes.