Collagen wound dressings with anti-inflammatory activity

Albu M., Ferdes M., KAYA D. A., Ghica M., Titorencu I., Popa L., ...Daha Fazla

Molecular Crystals and Liquid Crystals, cilt.555, ss.271-279, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 555
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1080/15421406.2012.635556
  • Dergi Adı: Molecular Crystals and Liquid Crystals
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.271-279
  • Anahtar Kelimeler: Collagen, fibroblast cells, niflumic acid, scaffolds, wound dressing
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

The aim of this study was to develop modern wound dressings such as controlled drug delivery systems. These systems consist in collagen as release support and niflumic acid as drug. The scaffolds were prepared by lyophilization in order to obtain porous structures and were evaluated by release profile of niflumic acid, water absorption, collagenase degradation and biocompatibility with fibroblast cells. The collagen scaffold with 0.75% niflumic acid solved in laurel oil was optimal in terms of biodegradability, absorbability and fibroblast cells biocompatibility. Thus, the obtained collagen scaffolds could be used as wound dressings with absorbent, antibacterial and anti-inflammatory properties. © 2012 Copyright Taylor and Francis Group, LLC.