Collagen wound dressings with anti-inflammatory activity


Albu M., Ferdes M., KAYA D. A., Ghica M., Titorencu I., Popa L., ...More

Molecular Crystals and Liquid Crystals, vol.555, pp.271-279, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 555
  • Publication Date: 2012
  • Doi Number: 10.1080/15421406.2012.635556
  • Journal Name: Molecular Crystals and Liquid Crystals
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.271-279
  • Keywords: Collagen, fibroblast cells, niflumic acid, scaffolds, wound dressing
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

The aim of this study was to develop modern wound dressings such as controlled drug delivery systems. These systems consist in collagen as release support and niflumic acid as drug. The scaffolds were prepared by lyophilization in order to obtain porous structures and were evaluated by release profile of niflumic acid, water absorption, collagenase degradation and biocompatibility with fibroblast cells. The collagen scaffold with 0.75% niflumic acid solved in laurel oil was optimal in terms of biodegradability, absorbability and fibroblast cells biocompatibility. Thus, the obtained collagen scaffolds could be used as wound dressings with absorbent, antibacterial and anti-inflammatory properties. © 2012 Copyright Taylor and Francis Group, LLC.