A subvulvar leiomyosarcoma in a Simmental cow - a case report Subvulvarni leiomiosarkom u krave simentalske pasmine - prikaz slučaja

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UYAR A., Düz E., Keleş Ö. F., Yaman T., Yener Z.

Veterinarski Arhiv, cilt.92, sa.2, ss.213-221, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.24099/vet.arhiv.1406
  • Dergi Adı: Veterinarski Arhiv
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.213-221
  • Anahtar Kelimeler: desmin, histopathology, Ki67, perineal subvulvar leiomyosarcoma, Simmental cow, surgery, vimentin, α-SMA
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

In this case, a mass located subcutaneously in the perineal subvulvar region of a six-year-old Simmental cow was examined clinically, pathomorphologically and immunohistochemically. Macroscopically, the solitary, whitish-yellow-tumor mass was 19x15x6 cm in size, weighed 1610 grams, and had a lobular structure with a few small cystic formations in the section. Histopathological examination revealed that the tumor parenchyma had smooth muscle-like cells with abundant cytoplasm, pleomorphic cells with blunt-ended or cigar-shaped nuclei, anisocytosis, anisokaryosis and karyomegaly. Immunohistochemically, strong positive expression for α-SMA, vimentin, Ki67 and slight positive for desmin were found, while immulolabeling for pancytokeratin (AE1/AE3), S-100, CD31 and CD34 were negative. In conclusion, on the basis of these findings, the tumor was diagnosed as leiomyosarcoma.