Akademik Veri Yönetim Sistemi
Pakistan Journal of Medical Sciences, cilt.27, sa.2, ss.361-364, 2011 (SCI-Expanded)
Objectives: We tried to understand what are the effects of the sickle cell diseases (SCD) on metabolic parameters, especially the body weight and height in the study. Methodology: The study was performed in the Hematology and Internal Medicine Polyclinics on SCDs and routine check up patients. Results: The study included 122 patients with SCDs (58 females) and 176 control cases. Mean age of the SCDs cases was 28.6 years. When we compared the patients and control groups, mean body weight and body mass index (BMI) were significantly reduced in the SCDs cases (71.6 vs. 57.8 kg and 24.9 vs. 20.7 kg/m2, p= 0.000 for both), whereas the mean heights were similar in both groups (166.1 vs. 168.5 cm, respectively, p>0.05). Similar to the decresed mean body weight and BMI, mean values of the low density lipoprotein cholesterol and high density lipoprotein cholesterol were significantly lower in the patients group (p= 0.000 for both), whereas the fasting plasma glucose and triglyceride values were unchanged between the groups (p>0.05). Additionally, probably parallel to the reduced mean body weight and BMI, mean values of the alanine aminotransferase (34.9 vs. 56.7 U/L, p= 0.000) and systolic and diastolic blood pressures were also significanly lower in the patients group (113.3 vs. 118.8 and 72.3 vs. 83.6 mmHg, respectively, p<0.01 for both), all of which can be explained by definition of the metabolic syndrome. Conclusion: Although the body weight can significantly be reduced by SCDs, the body height may strongly be determined by heredity.