A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening

Silfeler D. B., Tandogan B., Ayvaci H., Silfeler I., Yenidede I., Dayicioglu V.

Archives of Gynecology and Obstetrics, vol.284, no.6, pp.1331-1337, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 284 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.1007/s00404-011-1844-7
  • Journal Name: Archives of Gynecology and Obstetrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1331-1337
  • Keywords: Cervical ripening, Dinoprostone, Misoprostol, Oxytocin
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Objective: We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming. Study design: A total of 218 patients were enrolled to receive between one and three treatments according to physicians' options. The end points were: (1) vaginal delivery or Bishop score ≥8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ 2, Fisher, Advanced χ 2, and Kolmogorov-Smirnov tests. Tukey's HSD was used as a post hoc test. Results: Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥8 Bishop score at the end of 12 h, and cervical change of ≥4 Bishop scores within 12 h (p = 0.013). Conclusions: Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance. © Springer-Verlag 2011.