Akademik Veri Yönetim Sistemi
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.23, sa.4, ss.213-218, 2013 (SCI-Expanded, Scopus, TRDizin)
Poly (ADP-ribose) polymerase (PARP) family of enzymes is part of the DNA repair mechanism. One of these enzymes, PARP-1 is involved in detection of signal single-strand DNA breaks (SSBs) that leads to base excision repair (BER) mechanism. Breast cancer tumors that lack Breast cancer susceptibility gene 1 (BRCA1) and Breast cancer susceptibility gene 2 (BRCA2) are ineffective in DNA double-strand breaks (DSB) repair. Activity of the poly (ADP-ribose) polymerase (PARP) enzymes in these tumors is of interest as a lack of PARP activity leads to accumulation of SSBs that are converted to DSBs and accumulation of DSBs lead to irreparable DNA damage and cell death. Therefore inhibition of PARP in tumor cells might be effective in killing cancer tumors and activity of PARP inhibitors in selectively killing breast cancer tumors is currently being evaluated. In this study, expression of PARP-1 and cancer markers estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) were determined in a group of breast cancer patients to assess the potential for using PARP inhibitors against this form of cancer. Expression of PARP-1 was found not to correlate with the onset of breast cancer in the patients.