Akademik Veri Yönetim Sistemi
Cukurova Medical Journal, cilt.45, sa.1, ss.1-8, 2020 (ESCI)
Purpose: Genetic predisposition plays an important rolein the development of atherosclerosis in young patients.The aim of this study was to determine the relationshipbetween myocardial infarction and HLA antigens in youngpatients who had myocardial infarction in southern regionof Turkey.Materials and Methods: We enrolled 50 patients ( 36male, 14 female, mean age 45.0 ± 7.1 ) who hadmyocardial infarction before 45 years old in men and 55years old in women and 50 healthy subjects (31 male, 19female, mean age 51.5 ± 5.5 ) as a control group into thestudy. Venous blood samples were collected for HLAtissue typing and determining trombogenic factors.Histocompatibility antigens (HLA-A,B,C,-DQ,-DR) werestudied with Polymerase Chain Reaction (PCR)-SequanceSpesific Oligonucleotide typing (SSO) method.Results: Frequency of HLA antigens in patients andcontrols were 38% and 10% for HLA-A24, 40% and 10%for HLA-DQB2, 26% and 6% for HLA-DRB1-7 and 52%and 26% for HLA-DRB4-1. Chi square test revealed asignificant relation with the disease and the presence ofthese antigens. In the logistic regression analysis, smoking,Lp(a), homocysteine and HLA-DQB1 subtype wereindependently associated with development of MI inyoung patients.Conclusion: The presence of HLA-A24, HLA-DQB2,HLA-DRB1-7 and HLA-DRB4-1 may be used as geneticmarkers for the tendency to coronary artery disease insouthern region of Turkey