Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration


Ilhan N., Daglioglu M. C., Ilhan O., Coskun M., Tuzcu E. A., Kahraman H., ...Daha Fazla

Ocular Immunology and Inflammation, cilt.23, sa.4, ss.287-290, 2015 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/09273948.2014.921715
  • Dergi Adı: Ocular Immunology and Inflammation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.287-290
  • Anahtar Kelimeler: Age-related macular degeneration, blindness, inflammation, neutrophil/lymphocyte ratio, retinal drusen
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Purpose: To investigate the neutrophil/lymphocyte ratio (NLR) as an indicator of inflammation in patients with age-related macular degeneration (AMD).Methods: Patients were evaluated by a review of records. The study included 81 patients with dry AMD (group 1), 84 patients with wet AMD (group 2), and 80 healthy age- and sex-matched controls (group 3). The NLR of the patients was obtained from the hospital laboratory archive and was measured by dividing the neutrophil count by the lymphocyte count.Results: A significant difference was found in NLR values between groups 1 and 2 (p = 0.017), groups 2 and 3 (p < 0.001), and groups 1 and 3 (p < 0.001). In correlation analyses, NLR was correlated positively with age (r = 0.22, p <0.001) and disease severity (r = 0.40, p < 0.001).Conclusions: Patients with AMD have higher NLR compared with controls, and NLR correlates with disease severity. NLR may be used as a biomarker of inflammation in AMD.