Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration
Ocular Immunology and Inflammation, vol.23, no.4, pp.287-290, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2015
- Doi Number: 10.3109/09273948.2014.921715
- Journal Name: Ocular Immunology and Inflammation
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.287-290
- Keywords: Age-related macular degeneration, blindness, inflammation, neutrophil/lymphocyte ratio, retinal drusen
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
Purpose: To investigate the neutrophil/lymphocyte ratio (NLR) as an indicator of inflammation in patients with age-related macular degeneration (AMD).Methods: Patients were evaluated by a review of records. The study included 81 patients with dry AMD (group 1), 84 patients with wet AMD (group 2), and 80 healthy age- and sex-matched controls (group 3). The NLR of the patients was obtained from the hospital laboratory archive and was measured by dividing the neutrophil count by the lymphocyte count.Results: A significant difference was found in NLR values between groups 1 and 2 (p = 0.017), groups 2 and 3 (p < 0.001), and groups 1 and 3 (p < 0.001). In correlation analyses, NLR was correlated positively with age (r = 0.22, p <0.001) and disease severity (r = 0.40, p < 0.001).Conclusions: Patients with AMD have higher NLR compared with controls, and NLR correlates with disease severity. NLR may be used as a biomarker of inflammation in AMD.