Effects of Malathion in fetal kidney tissues in pregnant rats: Teratogenic effects induced by different doses Gebe ratlara farklı dozlarda uygulanan Malathionun fetüs böbrek dokusu üzerine teratojenik etkileri

Alp H., Sak M. E., Evsen M. S., Firat U., Evliyaoglu O., Penbegul N., ...More

Kafkas Universitesi Veteriner Fakultesi Dergisi, vol.18, no.2, pp.221-226, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2012
  • Journal Name: Kafkas Universitesi Veteriner Fakultesi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.221-226
  • Keywords: Fetus, Organophosphate, Pregnant rat, Prenatal exposure, Teratogenic effect
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

The aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys- it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects.