Bilateral Internal Carotid Artery Occlusion due to Homocystinuria: Case Report

Demiray D., Albayram S., YALÇINKAYA C., Hasiloglu Z.

TURKISH JOURNAL OF NEUROLOGY, vol.17, no.2, pp.106-109, 2011 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2011
  • Journal Name: TURKISH JOURNAL OF NEUROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.106-109
  • Hatay Mustafa Kemal University Affiliated: No

Abstract

The damage mechanism of homocystinuria that occurs due to cystathionine beta-synthase deficiency is not known. However, it is proposed that transmethylation disorders and NMDA-mediated excitotoxicity cause endothelial damage, thereby leading to vascular thrombosis and epileptic seizures. In this case report, the cranial magnetic resonance imaging (MRI) and MRI angiography of a 10-year-old boy with homocystinuria revealed bilateral internal carotid artery occlusion. The mechanisms of the emergence of clinical and radiological findings of homocystinuria are discussed.