Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model

YILDIZ H., Kalipci E., Oztas H., YILDIZ D.

Journal of Cancer Research and Therapeutics, cilt.15, sa.1, ss.231-236, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4103/jcrt.jcrt_1319_16
  • Dergi Adı: Journal of Cancer Research and Therapeutics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.231-236
  • Anahtar Kelimeler: Acetylsalicylic acid, azaserine, rats, sulfhydryl content
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Aim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal -SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.