The protective effect of rutin against methotrexate-induced nephrotoxicity in rats
Turkish Journal of Nephrology, cilt.30, sa.3, ss.218-223, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.5152/turkjnephrol.2021.4731
- Dergi Adı: Turkish Journal of Nephrology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.218-223
- Anahtar Kelimeler: Methotrexate, Nephrotoxicity, Rutin
- Hatay Mustafa Kemal Üniversitesi Adresli: Evet
Özet
Objective: This study was purposed to investigate the possible protective effects of rutin on kidney tissue in a methotrexate-induced nephrotoxicity rat model. Methods: Rats were randomly divided into 4 groups: control group, methotrexate (MTX, 20 mg/kg) group, rutin (RUT, 50 mg/kg/day) group, and methotrexate + rutin (MTX+RUT, 20 mg/kg + 50 mg/kg/day, respectively) group. Biochemical and histopathological analyzes were performed on kidney tissues of rats at the end of the study. Results: It was determined that kidney tissue damage determined in the MTX group was decreased in the MTX + RUT group; there were no degenerative changes in the tubular epithelium of the MTX + RUT group, and only mild degenerative changes were observed rather than hydropic degeneration seen in MTX group. Conclusion: This study suggests that rutin can be effective in preventing the toxic effects of methotrexate on the kidney.