The relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndrome


Akçay A. B., Çamsari A., Özcan T., Çiçek D., Akkuş N., Seyis S., ...More

Turk Kardiyoloji Dernegi Arsivi, vol.39, no.5, pp.371-377, 2011 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.5543/tkda.2011.01382
  • Journal Name: Turk Kardiyoloji Dernegi Arsivi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.371-377
  • Keywords: Angina pectoris, Aryldialkylphosphatase/blood, Coronary artery disease, Metabolic syndrome X
  • Hatay Mustafa Kemal University Affiliated: No

Abstract

Objectives: We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients with metabolic syndrome (MetS). Study design: The study included 21 patients (mean age 55±9 years) with MetS, stable angina pectoris, and angiographically shown CAD, 24 patients (mean age 51±10 years) with MetS and angiographically normal coroner arteries, and 28 healthy controls (mean age 49±12 years). Demographic and clinical characteristics, insulin levels, homeostasis model assessment of insulin resistance index, and PON-1 activity were assessed in all the groups. Severity of CAD was assessed using the Gensini score. Results: Paraoxonase-1 activity was significantly lower in patients with MetS compared to the control group (p=0.02). The two MetS groups with and without CAD exhibited similar characteristics in all the parameters including PON-1 activity (p>0.05). Univariate correlation analysis performed in MetS-CAD patients showed a significant negative correlation between the Gensini score and PON-1 activity (r=-0.48, p=0.02). The overall PON-1 activity of all the subjects showed no correlation with the parameters examined. Conclusion: Decreased PON-1 activity in patients with MetS compared to the control group suggests increased oxidative stress in MetS. Detection of similar PON-1 activity levels in MetS groups with and without CAD suggests that disturbance of oxidative-antioxidative balance occurs before the development of CAD. The negative correlation between the Gensini score and PON-1 activity implies that decreased PON-1 activity may be one of the etiologic causes of atherosclerotic progress in MetS. © 2011 Turkish Society of Cardiology.