Akademik Veri Yönetim Sistemi
Revista Cientifica de la Facultad de Veterinaria, cilt.35, sa.3, 2026 (SCI-Expanded, Scopus)
Adipokines regulate energy homeostasis. High-fat Western diet leads to obesity and disrupts adipocyte metabolism. Probiotics such as Lactoba cillus rhamno sus GG are effective in obesity management. This study investigates the effect of Lactob acillus rhamn osus GG on serum adipokine levels in rats fed a High-fat Western diet. Thirty 5-6 week old male Wistar albino rats (Rattus norvegic us dome stica) were randomly selected and divided into three groups: control (standard chow), W (45% fat), and a WLgroup supplemented orally with Lactoba cillus rham nosus GG in vegetable oil for 16 weeks. At the end of the study, blood samples were collected from rats via cardiac puncture, and serum adipokine levels were measured using ELISA kits. Body weight, naso-anal length, and BMI (body mass index) exhibited statistically significant increases in the W group. In the L actoba cillus rhamnosu s GG-supplemented group (WL), body weight and BMI decreased, while naso-anal length increased. SFRP5 and CT1 levels were low, and asprosin and vaspin levels were high in the Wgroup. CT1, vaspin, and asprosin levels increased in the La ctob acillu s rh amnosus GG-supplemented group. In conclusion, Lactob acillus rh amnosus GG alleviates obesity, increases naso-anal length, and reduces BMI in rats fed a High-fat Western diet. These results suggest that L. rh a mnosus may regulate serum CT1, vaspin, and asprosin levels, but not omentin or SFRP5 in the High-fat Western diet model.