Akademik Veri Yönetim Sistemi
British Journal of Dermatology, cilt.169, sa.5, ss.1081-1086, 2013 (SCI-Expanded, Scopus)
Background Carotid intima-media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor. Objective To evaluate the association between EFT and CIMT in patients with psoriasis. Methods This was a cross-sectional and observational study; 65 patients with psoriasis and 50 age- and sex- matched control subjects were included. Data about echocardiographic EFT, CIMT, anthropometric measurements and metabolic profile were obtained. Results The EFT and CIMT were significantly increased (7·3 ± 0·5 vs. 6·5 ± 0·5 mm, P < 0·01; 0·74 ± 0·11 vs. 0·60 ± 0·07 mm, P < 0·01, respectively) in patients with psoriasis compared with the controls. EFT was significantly correlated with CIMT (r = 0·69, P < 0·01). In a multiple linear regression model in which EFT was independently associated with psoriasis (β = 0·45, P < 0·01), age (β = 0·33, P = 0·01), CIMT (β = 0·50, P < 0·01), body mass index (β = 0·25, P = 0·01), high-sensitivity C-reactive protein (β = 0·32, P < 0·01) and duration of disease (β = 0·34, P = 0·03). Conclusions We demonstrated that EFT and CIMT are increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis. What's already known about this topic? The risk of myocardial infarction, stroke and cardiovascular mortality increases in patients with psoriasis. Carotid intima-media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor. What does this study add? EFT and CIMT are increased in patients with psoriasis compared with healthy controls. Echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis. © 2013 British Association of Dermatologists.