Lack of association between the Thr431Asn and Arg83Lys polymorphisms of the ROCK2 gene and diabetic retinopathy
Current Eye Research, cilt.35, sa.12, ss.1128-1134, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 12
- Basım Tarihi: 2010
- Doi Numarası: 10.3109/02713683.2010.507903
- Dergi Adı: Current Eye Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1128-1134
- Anahtar Kelimeler: Diabetic retinopathy, Genetic polymorphisms, Haplotype analysis, Rho-kinase, ROCK2
- Hatay Mustafa Kemal Üniversitesi Adresli: Hayır
Özet
Purpose: To analyze the genotype distributions and allele frequencies for ROCK2 Thr431Asn and Arg83Lys polymorphisms among the diabetic retinopathy patients in a Turkish population. Methods: In this case-control study, 335 patients with diabetes mellitus were recruited and divided into three groups according to non-proliferative (n=127), proliferative (n=85) diabetic retinopathy, and no retinopathy (n=123, served as a diabetic control group). Genomic DNA from the patients, and the nondiabetic healthy control cases (n=132) was analyzed by real-time PCR using a Light-Cycler. Results: Neither genotype distributions nor the allele frequencies for the Thr431Asn or Arg83Lys polymorphisms showed a significant difference between the groups. The haplotypes were also not significantly associated with diabetic retinopathy. Conclusion: These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population. © 2010 Informa Healthcare USA, Inc.