Lack of association between the Thr431Asn and Arg83Lys polymorphisms of the ROCK2 gene and diabetic retinopathy

Demiryurek A. T., Erbagci I., Oztuzcu S., Alasehirli B., Ozkara E., Seker M., ...Daha Fazla

Current Eye Research, cilt.35, sa.12, ss.1128-1134, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 12
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/02713683.2010.507903
  • Dergi Adı: Current Eye Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1128-1134
  • Anahtar Kelimeler: Diabetic retinopathy, Genetic polymorphisms, Haplotype analysis, Rho-kinase, ROCK2
  • Hatay Mustafa Kemal Üniversitesi Adresli: Hayır

Özet

Purpose: To analyze the genotype distributions and allele frequencies for ROCK2 Thr431Asn and Arg83Lys polymorphisms among the diabetic retinopathy patients in a Turkish population. Methods: In this case-control study, 335 patients with diabetes mellitus were recruited and divided into three groups according to non-proliferative (n=127), proliferative (n=85) diabetic retinopathy, and no retinopathy (n=123, served as a diabetic control group). Genomic DNA from the patients, and the nondiabetic healthy control cases (n=132) was analyzed by real-time PCR using a Light-Cycler. Results: Neither genotype distributions nor the allele frequencies for the Thr431Asn or Arg83Lys polymorphisms showed a significant difference between the groups. The haplotypes were also not significantly associated with diabetic retinopathy. Conclusion: These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population. © 2010 Informa Healthcare USA, Inc.