Synthesis of novel norephedrine-based chiral ligands with multiple stereogenic centers and their application in enantioselective addition of diethylzinc to aldehyde and chalcone

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Ünaleroğlı C., Aydın A. E., Demir A. S.

TETRAHEDRON ASYMMETRY, cilt.17, ss.742-746, 2006 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 17
• Basım Tarihi: 2006
• Dergi Adı: TETRAHEDRON ASYMMETRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
• Sayfa Sayıları: ss.742-746
• Hatay Mustafa Kemal Üniversitesi Adresli: Hayır

Özet

Novel norephedrine-based chiral ligands with multiple stereogenic centers were conveniently prepared from norephedrine

and N-substituted pyrrole. These novel chiral ligands were used to catalyze the enantioselective addition of diethylzinc to aldehydes

and to chalcone in high yields and with good to high enantioselectivities. The absolute configuration of products was found to be

affected by the stereogenic centers on the norephedrine part of the novel chiral ligands.